As with other vascular diseases, people with TAO are more likely to have high levels ofhomocysteine and low levels of folic acid. However, no research has tested folic acid as prevention or treatment for this disease.
One controlled study compared a type of niacin (vitamin B3) known as inositol hexaniacinate to the drug pyridinolcarbamate for the treatment of skin ulcers caused by PVD. A placebo was not included in this trial, and both 1.2 grams daily of inositol hexaniacinate and 1.5 grams daily of the drug produced beneficial results in about half of the patients.
As in many vascular diseases, people with AAA often have abnormal cholesterol and triglyceride levels, and their blood vessel walls contain evidence of free radical damage. However, it is not known whether lowering blood fats or taking free radical-destroying antioxidants will reduce the risk of AAA. The arterial walls of AAA are depleted of large molecules related to cartilage, including chondroitin sulfate, but no research has investigated whether supplements of chondroitin sulfate might help prevent problems with AAA. Copper is required for normal artery structure. Animal studies have shown that copper deficiency leads to weak aortic walls and rupture of the aorta. Combating deficiency with copper supplements prevented rupture in an animal study. Copper deficiency in humans with AAA has been suggested in some studies, but not in others. No studies have been done using copper supplements to prevent or manage aneurysms...
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